LISA The Painful has a large cast of characters, some of which are much stronger than others, and like most RPGs, you gain experience and level up by fighting.
However, several times in the game you are forced to make extremely hard choices, up to and including sacrificing the characters in your party (they permanently die). At another point you play Russian roulette by picking a party member to put the gun to their head and pull the trigger. Bad RNG? They're dead and gone forever.
If you don't know these events are coming up, you can very easily lose your favorite party/characters forever, and it's almost assured the ones you use are your strongest, since they're the ones you're using in your party.
They don't call it "The Painful" for no reason.
Telltale Games' The Walking Dead (season 1) was great for the first few episodes. I tried my best to make my choices really matter and not to save scum to go back and change my decisions. But at one point a character I really liked died, seemingly from a choice I made in error, and I went back to change it up.
That's when I discovered that the story itself is really on rails behind the scenes. If a character has the potential to die in one episode and you let them live, they are almost guaranteed to die in a future episode, so the writers didn't need to keep extrapolating branching narratives. Yes, the reactions and dialogue change based on your choices, but once I knew that none of my decisions actually decided the final outcome, it made me much less invested in the game.
This is pretty similar in season 2, AFAIK, though there were multiple endings depending on some choices, so at least some decisions mattered a little more. Never played the other seasons, but, yeah, it put a sour taste in my mouth.