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Shoot an infected deer in the head or have it otherwise die violently on the ground. Prions can last in the soil for years and years. Misfolded proteins are basically invulnerable, even in shit like autoclaves. If cows eat grass that has prions on them, that shit could potentially jump. And a lot of people ranch their cattle on public lands where infected deer are, and where wolves are unavailable due to politicians, who would otherwise prevent infected deer from spreading.
The best thing that we can do is have wolves clamp down on the few infected deer immediately rather than generate large pools of infection that then start cross-contaminating domestic livestock. Prions and ebola are the two things that really keep me up at night.
Interesting, I didn't know prions lasted so long on bare soil. I don't imagine it's a simple thing for a prion to jump from animal to animal though. Certainly not any less complex than jumping to humans? Right?
I'm not well-versed enough on prions to make an incredibly informed opinion. Apex predators somehow have managed to survive it for eons, though. Prions are extremely odd, and I'm sure one day we will figure out how to reverse their effect. There are some theories that prions could have formed the basis for life if life was seeded by asteroids, as they are incredibly resilient to heat, radiation, chemicals, etc.
From the CDC's website, it looks like CWD might not affect canids and might not affect humans, as we are just too different from the cloven-hoofed forest puppies. But much like consuming fish parasites that don't affect humans, it seems they don't recommend eating sick animals just on the off chance that you are patient zero for a new, fun, lethal protein :)