Entirety of outer wilds but especially when >!you find out there is no way to stop the sun from exploding. I just sat in the station staring as the sun expanded and blew up trying to process the info that the world is doomed.!< It was an extremely impactful moment in a game filled with them.
Another two are more recent for me but when >!Ardbert hands you the axe and the shadowbringers theme kicks in!< in Shadowbringers and in Endwalker when you >!walk up the crystal staircase with Alphinaud and Alisaie. You end the journey with the two that were there at the start. Gave me chills and moved me to tears.!<
Finally, in Disco Elysium when you >!break the news of the working class woman’s husbands death!< Absolutely broke me
Multiple from FFXIV.
“The rains have ceased, and we have been graced with another beautiful day. But you are not here to see it.”
“No more shall men have wings to bear him to paradise. Henceforth he shall walk.”
“In your darkest hour, in the blackest night…think of me…and I will be with you. Always. For where else could I go? Who else could I love but you?”
Honestly the list goes on and on.
Also the entirety of Mary’s letter from silent hill 2, but that is way too long to quote here.