Unless you're caught off-guard, spiders aren't much of a problem (in fact, they can be a nice food source, and spider mutations are very good). Just fish them out one by one, since they're very aggressive, they will spread out in some time (especially in swamps), and fire can be very annoying to deal with, I only use fire early game and when dealing with the electric plants, they die almost instantly by it and are afraid of it, deterring them from attacking. Or just chuck a molotov, as long as the mini-nuclear reactors aren't damaged it should be fine.
You don't seem troubled by grenade hacks, do you simply deal with them that way? It's a russian roulette, they're very fast and if you fail to break them, their detonation can deal 120 ish damage to all body parts even with a decent armor, plus bleeding, and if you have hollow bones you'll be toast.
The elec dicapacitance, protective lenses, and filtration system bions are quite good, the former now should actually be direclty better than a gas mask as it gives the same environmental protection for no encumberance, and does not consume bion power or mask cartridges, only some bion slots. It's also nice not having to equip, reload, and activate it each time you find some gas.
And yes, shogs are a no-no.
It'd be interesting to have something like the anarchy servers of MC. It'd be complicated though.