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I think one of the first things you’ll be interested to hear is modern definitions of ME/CFS don’t note fatigue as the most disabling symptom but a disease process called post-exertional malaise, wherein a person’s entire disease can worsen (sometimes permanently) based on the amount of energy they use.
It’s really fascinating, A recent study by Wust et al. found muscle clotting and abnormalities following exertion in people with ME/CFS.
Also people with ME are the only known disease group to preform markeldy worse in specific markers on a 2 day CPET. Which would serve as a biomarker if it were not for the fact doing the test can worsen people’s disease permanently.
I highly recommend this summarising article on the issue: https://www.nationalgeographic.com/premium/article/long-covid-patients-exercise-bad-medicine