Science

28 readers

1 users here now

This magazine is dedicated to discussions on scientific discoveries, research, and theories across various fields, including physics, chemistry, biology, astronomy, and more. Whether you are a scientist, a science enthusiast, or simply curious about the world around us, this is the place for you. Here you can share your knowledge, ask questions, and engage in discussions on a wide range of scientific topics. From the latest breakthroughs to historical discoveries and ongoing research, this category covers a wide range of topics related to science.

founded 2 years ago

Tumour immune rejection triggered by activation of α2-adrenergic receptors - Nature (www.nature.com)

submitted 1 year ago by ViridianNott@kbin.social to c/science@kbin.social

2 comments fedilink hide all child comments

Layman's explanation: This sounds like it could a huge step forward in fighting cancer! While this result is bound to only be applicable and practical for a subset of tumors, it gives rise to the possibility of a new or existing drug that can weaken tumors and make them easier to fight.

The α2-adrenergic receptors mentioned in the study play a crucial role in the regulation of a ubiquitous signaling molecule called cAMP. Using an agonist (a small molecule that activates a receptor) for α2-adrenergic receptors would decrease cAMP signaling in immune cells, which can provide them the cues necessary to activate against a tumor. In short, tumors normally do a good job of hiding from your immune cells, and activating their α2-adrenergic receptors seems to partially circumvent this problem.

I'm a biologist who is accustomed to interpreting the fine details of these sorts of studies, so do feel free to reach out with any specific questions.

top 2 comments

sorted by: hot top controversial new old

[–] mirror_slap@kbin.social 1 points 1 year ago (1 children)

This sounds like something people in high risk groups may be able to take as a prophylactic. For example women with the breast cancer gene.

[–] ViridianNott@kbin.social 1 points 1 year ago

Cool idea! I do feel that a drug like this could exacerbate the risk of autoimmune diseases, though