Metabolic Health

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Paper - Omega-3 and omega-6 Fatty acids in blood and breast tissue of high-risk women and association with atypical cytomorphology - 2015 (doi.org)

submitted 2 days ago by jet@hackertalks.com to c/metabolic_health@lemm.ee

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TLDR - Women who had a high omega-6 to omega-3 ratio in their fat where at elevated risk for developing breast cancer.

Seed oils (vegetable oils) are the major dietary driving source of omega-6s. It seems reasonable that seed oils have a outsized cancer risk.

The ratio of omega-3 to omega-6 fatty acids, especially the long-chain eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) to arachidonic acid (AA) ratio, is inversely associated with breast cancer risk. We measured the association between cytologic atypia, a biomarker for short-term risk of breast cancer development, and omega-3 and omega-6 fatty acid intake and levels in blood and breast tissue. Blood and benign breast tissue, sampled by random periareolar fine-needle aspiration (RPFNA), was obtained from 70 women at elevated risk for breast cancer. Self-reported dietary intake was assessed by the NCI's Food Frequency Questionnaire. The fatty acid composition of five lipid compartments, red blood cell, plasma and breast phospholipids, and plasma and breast triaclyglycerides (TAG), was analyzed by gas chromatography as weight percent. Median daily intakes of EPA+DHA and total omega-3 fatty acids were 80 mg and 1.1 g, respectively. The median total omega-3:6 intake ratio was 1:10. Compared with women without atypia, those with cytologic atypia had lower total omega-3 fatty acids in red blood cell and plasma phospholipids and lower omega-3:6 ratios in plasma TAGs and breast TAGs (P < 0.05). The EPA+DHA:AA ratio in plasma TAGs was also lower among women with atypia. This is the first report of associations between tissue levels of omega-3 and omega-6 fatty acids and a reversible tissue biomarker of breast cancer risk. RPFNA cytomorphology could serve as a surrogate endpoint for breast cancer prevention trials of omega-3 fatty acid supplementation.

Full paper at above link

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[–] RubberElectrons@lemmy.world 2 points 2 days ago

Thanks for this. Very interesting results..

[–] jet@hackertalks.com 1 points 2 days ago* (last edited 2 days ago)

Notes:

Over the past century, consumption in the United States of omega-6 (n-6) fatty acids has increased dramatically, mostly from corn and soybean oil, whereas omega-3 fatty acid intake has remained stable (9). This high omega-6 intake relative to omega-3 fatty acids may contribute to breast cancer risk, because a low omega-3:6 ratio in tissue can create a proinflammatory milieu (5, 6) and thereby promote tumor formation and progression

Assessing this relationship is complicated by problems assessing omega-3 and omega-6 intake from food frequency questionnaires (FFQ; 16) and inconsistent results among different populations

two general conclusions and a hypothesis. First, women consuming their usual diet have a low intake of omega-3 relative to omega-6 fatty acids that is reflected in the omega-3:6 ratio in multiple tissues.

we found inverse associations between tissue levels of long-chain omega-3 fatty acids and omega-3:6 ratios and a reversible biomarker of breast cancer risk

Thoughts:

It would be reasonable to reduce or eliminate dietary omega-6 sources, such as seed oils (vegetable oils) for people who are concerned with breast cancer.

The papers make takeaway about omega-3 supplements is one approach, but I think its being indirect - either the authors believe seed oils are necessary, or they don’t want to get into a fight about removing seed oils from the diet. The advice seems backwards.