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I had fantastic results with ketamine (specifically Spravato / esketamine)! After the 12-session course, I truly felt like a whole new person.
At the end of the course, the clinic offered to let me continue treatments on a "maintenance" schedule of 1 session every 2 weeks. I declined the offer because the treatments were a little pricey, the clinic was far from home, and my mood felt positive and stable. Unfortunately, over the next 9 months or so, my mood slid all the way back down to where it had been before the ketamine. So, I recently called the clinic and re-enrolled. I'm hoping that it will have the same effect this time and that I can stick around on the maintenance plan for a long time.
As with all such treatments, your mileage may vary in terms of both the size and the duration of the effect. But I highly recommend it if you can afford the time and money! I'm on my phone and typing is slow, so I won't add more detail right now; but I'm happy to answer questions, if you have any!