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It's not just time zones and leap seconds. SI seconds on Earth are slower because of relativity, so there are time standards for space stuff (TCB, TGC) that use faster SI seconds than UTC/Unix time. T2 - T1 = [God doesn't know and the Devil isn't telling.]
Not even going to general relativity, as this comics suggests to experience time slowing down due to gravity, the events are not just at time, but also at particular location in space relative particular inertial system. Not specifying it, and not specifying the inertial system for which the final answer is needed makes it impossible to calculate even in special relativity, without effects of gravity.
Here's the shortlist of horrors I've had to deal with in my career:
Things I've read about but haven't needed to deal with personally:
The one thing I really don't care about is relativity
it's all relative anyway
We can divide by t and then we get 2-1=1. Simples!