In static electric fields, sure. But the real world has rapidly changing electric fields, and mapping concepts like voltage or resistance to a time dimension starts to require imaginary numbers (and the complex analogue to resistance goes by a different name of impedance). And once you're modeling electricity through those concepts, you can have high current in a particular moment in time where the voltage might not be high. Or where the implied voltage is very high but was actually more of an effect than a cause.

In other words, if you're simply talking about "resistance," you're already in the wrong domain to be analyzing electrical safety properly.