For me it's Corner Gas. I still think it's pretty funny and there's a decent amount of references to Canadian stuff but not enough to be off-putting. I feel like an American wouldn't be confused watching it even if some of the references get a bit dated overtime.
I have only seen a bit of the animated version in waiting rooms.
In the order they popped into my head:
Letterkenny, Canada’s Worst Driver, The Red Green Show, Degrassi
Canada's Worst Driver was so good! A perfect mix of educational, hilarious, and reality! Seeing people improve over time is very satisfying for some reason. It kinda died off after season 13 or so when they cranked up the reality TV aspects.
Also Canada's Worst Handyman! Just as dangerous, with contestants who are just as flagrant about safety.